{"tr":"

Glutatyon Nedir? Ne \u0130\u015fe Yarar?<\/h3>\r\n

\r\n

\u00a0<\/p>\r\n

Glutatyon, h\u00fccrelerin enerji santralleri olan mitokondrilerin sa\u011fl\u0131kl\u0131 bir \u015fekilde \u00e7al\u0131\u015fmas\u0131 i\u00e7in gereklidir.\u00a0Hasarlanm\u0131\u015f veya i\u015flev bozuklu\u011fu olan mitokondrilerin kanserle\u015fme s\u00fcrecinde kritik bir yeri vard\u0131r. Mitokondrilerin \u00e7al\u0131\u015fmas\u0131 toksinler veya sa\u011fl\u0131ks\u0131z h\u00fccresel ortam nedeniyle bozuldu\u011funda h\u00fccre solunum i\u00e7in oksijen yerine glukoz (\u015feker) kullan\u0131lan daha ilkel bir solunum formuna ge\u00e7ti\u011finde kanserle\u015fmektedir.<\/p>\r\n

Sa\u011fl\u0131kl\u0131 kalmak, performans\u0131n\u0131z\u0131 art\u0131rmak, hastal\u0131klar\u0131 \u00f6nlemek ve ya\u015flanman\u0131n etkilerinden korunmak,\u00a0 ba\u011f\u0131\u015f\u0131kl\u0131k i\u015flevi ve enflamasyonun kontrol\u00fc i\u00e7in glutatyon d\u00fczeyleri y\u00fcksek tutulmal\u0131d\u0131r.\u00a0Ara\u015ft\u0131rmalar y\u00fcksek glutatyon d\u00fczeylerinin kas hasar\u0131n\u0131 azaltt\u0131\u011f\u0131n\u0131, kaslar\u0131n iyile\u015fme s\u00fcresini k\u0131saltt\u0131\u011f\u0131n\u0131, kas kuvveti ve dayan\u0131kl\u0131l\u0131\u011f\u0131n\u0131 art\u0131rd\u0131\u011f\u0131n\u0131 ve metabolizmay\u0131 ya\u011f depolama yerine kas yap\u0131m\u0131na kayd\u0131rd\u0131\u011f\u0131n\u0131 g\u00f6stermektedir.<\/p>\r\n

Glutatyon, sa\u011fl\u0131kl\u0131 kalmak ve hastal\u0131ktan korunmak i\u00e7in en \u00f6nemli molek\u00fcllerden biridir.\u00a0Ya\u015flanma, kanser, kalp damar hastal\u0131klar\u0131, bunama (demans) ve ba\u015fka bir\u00e7ok kronik\/dejeneratif hastal\u0131\u011f\u0131n \u00f6nlenmesinde temel \u00f6neme sahip olan glutatyon \u00fc\u00e7 yap\u0131 ta\u015f\u0131ndan olu\u015fur, bunlar\u00a0 sisteine, glisin\u00a0 ve glutamin\u00a0 aminoasitleridir. Glutatyon v\u00fccudumuzda do\u011fal olarak \u00fcretilir. Glutatyona \u201cana anti-oksidan\u201d denilmesinin sebebi, onun serbest radikalleri yakalayarak karaci\u011fere ta\u015f\u0131r ve burada\u00a0 kendisini\u00a0 yenileyerek tekrar i\u015fine geri d\u00f6nmesidir. Serbest radikaller, \u00e7o\u011fu zaman normal h\u00fccre metabolik oksidasyonunun yan \u00fcr\u00fcnleri ve toksik at\u0131klar\u0131d\u0131r. Anti-oksidanlar taraf\u0131ndan etkisiz hale getirilmediklerinde otoimm\u00fcn hastal\u0131klara, kanser gibi kronik hastal\u0131klara yol a\u00e7abilirler.Glutatyon Nedir Ne \u0130\u015fe Yarar<\/p>\r\n

Glutatyon\u00a0Eksikli\u011fi<\/h3>\r\n

V\u00fccut do\u011fal yoldan glutatyon \u00fcretmekte ama bu ya\u015fla birlikte azalmaktad\u0131r. Toksinler de glutatyon d\u00fczeylerinin azalmas\u0131na neden olmaktad\u0131r.\u00a0Glutatyon azald\u0131\u011f\u0131nda serbest radikallere kar\u015f\u0131 korunamad\u0131\u011f\u0131m\u0131z i\u00e7in bu molek\u00fcller v\u00fccut yap\u0131lar\u0131na zarar verebilmektedir.\u00a0<\/p>\r\n

Aktif Glutatyon (GSH): Glutatatyon serbest radikalleri toplayarak doydu\u011funda karaci\u011ferde kendini yenilemektedir. \u0130deal \u015fartlarda glutatyonun %10\u2019u inaktif (oksitlenmi\u015f) durumda iken %90\u2019\u0131 aktif formdad\u0131r. GSH olarak da bilinen aktif glutatyon %90\u2019\u0131n alt\u0131nda d\u00fc\u015ft\u00fc\u011f\u00fcnde serbest radikallerle sava\u015f\u0131 kaybetmeye ba\u015flar\u0131z. Toksinler daha da birikti\u011finde GSH azalmaya devam eder. GSH %70\u2019in alt\u0131na d\u00fc\u015ft\u00fc\u011f\u00fcnde ba\u011f\u0131\u015f\u0131kl\u0131k sisteminde bozulma g\u00f6r\u00fcl\u00fcr.<\/p>\r\n

Eksikli\u011finin Sebepleri Nelerdir?\u00a0<\/h3>\r\n

\r\n
• V\u00fccudumuzdaki glutatyon (GSH) d\u00fczeylerindeki eksiklik i\u00e7 ve d\u0131\u015f fakt\u00f6rler olmak \u00fczere iki kategoriye ba\u011fl\u0131 olabilir.<\/li>\r\n
• \u0130\u00e7 fakt\u00f6rler v\u00fccudumuzda ba\u011f\u0131\u015f\u0131kl\u0131k, DNA onar\u0131m\u0131, oksidatif stresten korunma gibi \u00e7e\u015fitli s\u00fcre\u00e7lerin \u00f6nemli bir par\u00e7as\u0131 olan glutatyona duyulan gereksinimin artmas\u0131yla ilgilidir.<\/li>\r\n
• Her g\u00fcn maruz kald\u0131\u011f\u0131m\u0131z toksik ve zararl\u0131 maddeler gibi d\u0131\u015f fakt\u00f6rler\u00a0 kayda de\u011fer miktarda glutatyonun detoksifikasyon i\u00e7in kullan\u0131lmas\u0131 sonucunu do\u011furur.\u00a0\r\n

  Bu maddelerden baz\u0131lar\u0131 \u015funlard\u0131r:<\/p>\r\n<\/li>\r\n

• Asetaminofen (parasetamol) ,<\/li>\r\n
• Aseton, \u00e7\u00f6z\u00fcc\u00fcler (tiner),<\/li>\r\n
• Akaryak\u0131t ve yan \u00fcr\u00fcnleri,<\/li>\r\n
• A\u011f\u0131r metaller (civa (di\u015f dolgular\u0131, a\u015f\u0131lar, d\u00f6vmeler), kur\u015fun, kadmiyum, bak\u0131r vb.),<\/li>\r\n
• B\u00f6cek \u00f6ld\u00fcr\u00fcc\u00fcler (pestisitler), zirai m\u00fccadele ila\u00e7lar\u0131 (herbisidler),<\/li>\r\n
• Nitratlar ve kimyasal g\u0131da katk\u0131lar\u0131 (salam, sosis, t\u00fcts\u00fclenmi\u015f g\u0131dalar vb),<\/li>\r\n
• Yapay tatland\u0131r\u0131c\u0131 aspartam,<\/li>\r\n
• Sentetik g\u0131da boyalar\u0131,<\/li>\r\n
• Benzopirenler (sigara duman\u0131, mangal duman\u0131, egzos duman\u0131 vb.),<\/li>\r\n
• Alkol,<\/li>\r\n
• Ev temizlik \u00fcr\u00fcnleri (deterjanlar, \u00e7ama\u015f\u0131r yumu\u015fat\u0131c\u0131lar, oda kokular\u0131, naftalin, temizlik malzemeleri, beyazlat\u0131c\u0131lar vb.),<\/li>\r\n
• Mutfak malzemeleri (yap\u0131\u015fmayan tava kaplamalar\u0131, plastik saklama kaplar\u0131, konserve kutular\u0131 ve karton ambalajlar\u0131n i\u00e7 Kaplamalar\u0131 vb.),<\/li>\r\n
• Formaldehid ve stiren (fotokopi ve printer toner m\u00fcrekkepleri),<\/li>\r\n
• Klorlu su,<\/li>\r\n
• R\u00f6ntgen \u0131\u015f\u0131nlar\u0131,<\/li>\r\n
• UV radyasyon,<\/li>\r\n
• Elektromanyetik alanlar (EMF),<\/li>\r\n
• End\u00fcstriyel at\u0131klar,<\/li>\r\n
• Di\u011fer d\u0131\u015f fakt\u00f6rler,<\/li>\r\n
• Yetersiz beslenme \u2013 kofakt\u00f6r olan vitamin ve minerallerin eksikli\u011fi sonucunda glutatyon sentezi yetersiz kal\u0131r, ba\u015fka Antioksidanlar\u0131n yetersizli\u011fi de glutatyonun harcanmas\u0131na neden olur,<\/li>\r\n
• A\u015f\u0131r\u0131 egzersiz \u2013 v\u00fccutta fazla miktarda serbest radikal olu\u015fmas\u0131 sonucunda glutatyonu harcanmas\u0131na neden olur,<\/li>\r\n
• Kronik stres,<\/li>\r\n
• Kayg\u0131, endi\u015fe,<\/li>\r\n
• Depresyon,<\/li>\r\n<\/ul>\r\n

  
  Gece saatlerinde \u0131\u015f\u0131\u011fa maruz kal\u0131nmas\u0131 melatonin sal\u0131nmas\u0131n\u0131 bask\u0131layarak glutatyonun azalmas\u0131na neden olur (ba\u015f ucu lambalar\u0131, cep telefonu, tablet gibi cihazlar\u0131n ekran\u0131ndan yay\u0131lan mavi \u0131\u015f\u0131k);
  20 ya\u015f\u0131ndan sonra do\u011fal glutatyon \u00fcretimi her on y\u0131lda ortalama %10 azalmaktad\u0131r.<\/p>\r\n

  Bu fakt\u00f6rlerin t\u00fcm\u00fcnden ka\u00e7\u0131nmam\u0131z m\u00fcmk\u00fcn de\u011fildir ama pek \u00e7o\u011funu d\u00fczenli ya\u015fam tarz\u0131, toksinlerden ka\u00e7\u0131nma ve detoks yaparak minimize edebiliriz.<\/p>\r\n

  Glutatyon D\u00fczeylerini Art\u0131ran Besinler ve Destekler<\/h3>\r\n

  \r\n
  • Karaci\u011ferde glutatyon \u00fcretimini art\u0131rmaya yard\u0131mc\u0131 olan besinler (glutatyon prek\u00fcrs\u00f6rleri) aras\u0131nda k\u00fck\u00fcrtten zengin olan sar\u0131msak, so\u011fan, brassica grubu sebzeler (brokoli, lahanagiller, su teresi, karnabahar, br\u00fcksel lahanas\u0131), radika, \u015falgam say\u0131labilir.<\/li>\r\n
  • N-acetyl-cysteine (NAC) glutatyon \u00fcretimini uyaran de\u011ferli bir destektir. Ucuz ve h\u0131zl\u0131 etkilidir. NAC ile GSH d\u00fczeylerindeki y\u00fckselme birka\u00e7 saat s\u00fcren ge\u00e7ici bir y\u00fckselmedir.<\/li>\r\n
  • SAMe \u2013 S-adenosyl-methionine \u2013 k\u0131smen sisteine d\u00f6n\u00fc\u015ft\u00fcrelen bir methionin t\u00fcr\u00fcd\u00fcr, siroz ve kolestaz tedavisinde kullan\u0131l\u0131r. Duygu durumunu stabilize eden pop\u00fcler bir destektir. \u00a0<\/li>\r\n
  • Folat, vitamin B6 ve vitamin B12, biotin gibi metilasyon n\u00fctrientlerini i\u00e7eren\u00a0karaci\u011fer, mercimek, \u0131spanak, ku\u015fkonmaz, avokado, maydanoz, pancar, b\u00f6r\u00fclce t\u00fcketilmesi \u00f6nerilir.<\/li>\r\n
  • Melatonin hormonu known uyku ve uyan\u0131kl\u0131k d\u00f6ng\u00fcs\u00fcn\u00fc d\u00fczenleyen hormondur, beyindeki epifiz bezi taraf\u0131ndan \u00fcretilir. Melatonin kana gece sal\u0131n\u0131r ve \u00fcretimi b\u00fcy\u00fck \u00f6l\u00e7\u00fcde \u0131\u015f\u0131\u011fa ba\u011fl\u0131d\u0131r. \u00a0Melatonin ayn\u0131 zamanda \u00e7ok g\u00fc\u00e7l\u00fc bir antioksidand\u0131r. Ba\u015fka antikosidanlar\u0131 uyarma \u00f6zelli\u011fi vard\u0131r. \u00a0Melatoninin beyin, karaci\u011fer, kaslar ve kanda GSH d\u00fczeylerinin etkili bi\u00e7imde art\u0131rd\u0131\u011f\u0131 g\u00f6sterilmi\u015ftir.\u00a0Bilinen tek do\u011fal melatonin kayna\u011f\u0131 vi\u015fnedir.\u00a0<\/li>\r\n
  • Magnezyum glutatyon sentezi i\u00e7in \u00f6nem ta\u015f\u0131yan gamma glutamil transpeptidaz enziminin \u00e7al\u0131\u015fmas\u0131 i\u00e7in gerekli olan bir mineraldir.<\/li>\r\n
  • G\u00fcnde 490- 700 mg al\u0131nmas\u0131 \u00f6nerilmektedir.\u00a0Bal\u0131k, \u0131spanak, kabak, balkaba\u011f\u0131 \u00e7ekirde\u011fi, ay\u00e7i\u00e7e\u011fi \u00e7ekirde\u011fi, fasulyegiller, ceviz, badem, yerf\u0131st\u0131\u011f\u0131 zengin magnezyum kaynaklar\u0131d\u0131r.\u00a0<\/li>\r\n
  • \u00c7inko eksikli\u011fi \u00f6zellikle k\u0131rm\u0131z\u0131 kan h\u00fccrelerinde aktif glutatyon d\u00fczeylerinin d\u00fc\u015fmesine yol a\u00e7ar. Ancak y\u00fcksek \u00e7inko d\u00fczeyleri de toksiktir. Yeti\u015fkinlerde \u00f6nerilen g\u00fcnl\u00fck al\u0131m 8-11 mg d\u0131r.\u00a0En zengin \u00e7inko kaynaklar\u0131 istiridye, k\u0131rm\u0131z\u0131 ve beyaz et, kabuklu deniz \u00fcr\u00fcnleridir. Bitkisel kaynaklardaki \u00e7inkonun biyoyararlan\u0131m\u0131 hayvansal kaynaklara nazaran \u00e7ok d\u00fc\u015f\u00fckt\u00fcr.<\/li>\r\n
  • Selenyum, v\u00fccudun glutatyon \u00fcretimi ve geri d\u00f6n\u00fc\u015f\u00fcm\u00fc i\u00e7in \u00f6nemlidir.\u00a0Brezilya f\u0131nd\u0131\u011f\u0131, sardalya, pisi bal\u0131\u011f\u0131, otlak hayvan\u0131 etleri, hindi, karaci\u011fer, tavuk, yumurta, \u0131spanak selenyumdan zengin g\u0131dalard\u0131r.<\/li>\r\n
  • Milk thistle (silymarin) glutatyon d\u00fczeylerini y\u00fckseltir. Karaci\u011feri temizleyici, koruyucu ve yenileyici \u00f6zelli\u011fiyle tan\u0131nmaktad\u0131r.<\/li>\r\n
  • \u03b1-Lipoik Asit aktif glutatyon (GSH) d\u00fczeylerinin artmas\u0131na yard\u0131mc\u0131 olan bir destektir. G\u00fcnde 300-1200 mg Alfa lipoik asit ayr\u0131ca ins\u00fclin duyarl\u0131l\u0131\u011f\u0131n\u0131 art\u0131rmakta ve diyabetik n\u00f6ropati semptomlar\u0131n\u0131 azaltmaktad\u0131r.<\/li>\r\n<\/ul>\r\n

    Fiziksel aktivite glutatyon d\u00fczeylerinin artmas\u0131n\u0131 sa\u011flar.<\/h3>\r\n

    Haftada en az \u00fc\u00e7 defa g\u00fcnde 30 dakikal\u0131k yo\u011fun egzersiz v\u00fccudun antioksidan savunmas\u0131n\u0131 art\u0131rmaktad\u0131r.<\/p>\r\n

    C Vitamini k\u0131rm\u0131z\u0131 kan h\u00fccrelerinde ve lenfositlerde glutatyon d\u00fczeyini art\u0131r\u0131r.\u00a0Turun\u00e7giller (portakal, greyfurt), k\u0131rm\u0131z\u0131 ve ye\u015fil biber, \u00e7ilek, kivi C vitamininden zengin besin kaynaklar\u0131d\u0131r.\u00a0<\/p>\r\n

    E (karma tokoferol formunda) vitamini glutatyon ile birlikte \u00e7al\u0131\u015fan \u00f6nemli bir antioksidand\u0131r. Glutatyonun geri d\u00f6n\u00fc\u015f\u00fcm\u00fcne (C vitamini ile birlikte) yard\u0131mc\u0131 olur.\u00a0Badem, tatl\u0131 patates, avokado, \u0131spanak, ay\u00e7i\u00e7e\u011fi, balkaba\u011f\u0131, alabal\u0131k, zeytinya\u011f\u0131 E vitamininden zengindir.<\/p>\r\n

    Glutatyon \u00fcretimini uyaran baharatlar zerde\u00e7al, tar\u00e7\u0131n, kakule ve \u00e7\u00f6rek otudur.<\/p>\r\n

    Glutatyondan Zengin Besinler mg \/ 100g<\/p>\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n

    Besin<\/td>\r\n	GSH Miktar\u0131<\/td>\r\n<\/tr>\r\n
    Ku\u015fkonmaz<\/td>\r\n	28.3<\/td>\r\n<\/tr>\r\n
    Avokado<\/td>\r\n	27.7<\/td>\r\n<\/tr>\r\n
    Ispanak<\/td>\r\n	11.4<\/td>\r\n<\/tr>\r\n
    Bamya<\/td>\r\n	11.3<\/td>\r\n<\/tr>\r\n
    Brokoli<\/td>\r\n	9.1<\/td>\r\n<\/tr>\r\n
    Kavun<\/td>\r\n	9.0<\/td>\r\n<\/tr>\r\n
    Domates<\/td>\r\n	9.0<\/td>\r\n<\/tr>\r\n
    Havu\u00e7<\/td>\r\n	7.9<\/td>\r\n<\/tr>\r\n
    Greyfurt<\/td>\r\n	7.9<\/td>\r\n<\/tr>\r\n
    Portakal<\/td>\r\n	7.3<\/td>\r\n<\/tr>\r\n
    Kabak<\/td>\r\n	7.0<\/td>\r\n<\/tr>\r\n
    \u00c7ilek<\/td>\r\n	6.9<\/td>\r\n<\/tr>\r\n
    Karpuz<\/td>\r\n	6.6<\/td>\r\n<\/tr>\r\n
    Papaya<\/td>\r\n	5.8<\/td>\r\n<\/tr>\r\n
    K\u0131rm\u0131z\u0131 biber<\/td>\r\n	5.5<\/td>\r\n<\/tr>\r\n
    \u015eeftali<\/td>\r\n	5.0<\/td>\r\n<\/tr>\r\n
    Limon<\/td>\r\n	4.8<\/td>\r\n<\/tr>\r\n
    Mango<\/td>\r\n	4.3<\/td>\r\n<\/tr>\r\n
    Muz<\/td>\r\n	4.1<\/td>\r\n<\/tr>\r\n
    Karnabahar<\/td>\r\n	4.0<\/td>\r\n<\/tr>\r\n
    Ceviz<\/td>\r\n	3.7<\/td>\r\n<\/tr>\r\n
    Salatal\u0131k<\/td>\r\n	3.5<\/td>\r\n<\/tr>\r\n
    Ye\u015fil dolmal\u0131k biber<\/td>\r\n	3.4<\/td>\r\n<\/tr>\r\n
    Elma<\/td>\r\n	3.3<\/td>\r\n<\/tr>\r\n
    \u00dcz\u00fcm<\/td>\r\n	2.7<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n \u00a0<\/p>\r\n \u0130ntraven\u00f6z (IV) glutatyon \u00a0\u2013 \u015eiddetli glutatyon noksanl\u0131\u011f\u0131 olan kanser tedavisi ve \u00a0HIV\/AIDS tedavisi gibi durumlarda ya da genetik mutasyonlar veya ba\u015fka nedenlerden \u00f6t\u00fcr\u00fc kendi glutatyonlar\u0131n\u0131 yeterli \u015fekilde \u00fcretemeyen ki\u015filerde ba\u015fvurulan damar i\u00e7i uygulamad\u0131r. Hastalardaki t\u0131bbi duruma g\u00f6re, IV glutatyon haftal\u0131k veya g\u00fcnl\u00fck olarak d\u00fczenli bi\u00e7imde uygulanmal\u0131d\u0131r. Glutatyon IV yoldan verildi\u011finde kan ak\u0131m\u0131ndaki yar\u0131lanma \u00f6mr\u00fc \u00e7ok k\u0131sa olup ortalama 14 dakikad\u0131r. IV glutatyon 2,000 mg (2 g) dozunda verildi\u011finde h\u00fccrelerin alabilece\u011fi sistein \u015feklinde birikir. Uygulamadan 90 dakika sonra idrarda glutatyon ve sistein at\u0131l\u0131m\u0131nda s\u0131ras\u0131yla 300- ve 10-kat art\u0131\u015f olur.<\/p>","en":""}